What temperature to cook a pork tenderloin at?

Despite the currently accepted answer, there is no single best method to cook pork tenderloin. The main issue is getting it to a final internal temperature of about 145 F to 155 F (63 C to 68 C) depending on your preferences. If cooked to well done (above about 165 F, 74 C), it will be tough and rubbery as it has very little internal fat or collagen.

The actual temperature you cook it at can vary considerably depending on the method. In all cases, you want to check the internal temperature with an instant read thermometer.

In all cases, a resting period (which empirically allows more of the juices to be retained) of about 5-10 minutes is a good idea before serving or slicing.

The method advised in the current accepted answer is certainly effective, and can be delicious, but any method which gets the pork to the desired internal temperature without overcooking it will also work.

This can be accomplished in a variety of ways, including:

• Pan roasting. Pan searing and then finishing in a moderate oven (about 350 F, 175 C although there is flexibility here if you have other dishes to finish) is certainly one very effective method for cooking a pork tenderloin, but any method that brings it to the desired temperature will work.

• Roasting then searing. The reverse technique, which may give more tender results, would be to cook it in a slow oven (95 C) until it reaches the desired internal temperature, and then pan sear it for browning and deliciousness—the initial cooking dries the surface and allows the sear to develop flavor rapidly with minimal over cooking of the exterior.

• Grilling, first searing then indirect. While more difficult to control, this idea can be applied on the grill: sear the tenderloin over the hot part of the coals until it has a nice golden crust, then move it to indirect heat to cook through to the desired temperature. On a grill, controlling the absolute temperature is more difficult so I am not mentioning them, although you can take the oven method temperatures as a guide.

• Sous-vide. Some modernists might suggest putting it in a sous-vide water bath at 145 F (63 C) or even 135 F (57 C) for 2 1/2 to three hours (or until convenient to serve, although Yossarian recommends no more than 4 hours for lean meats like pork tenderloin to prevent it becoming mushy), and then finishing it with a torch or by pan searing. This allows complete control of the final internal temperature, but makes the final sear more difficult as the exterior is not dried.

• Sauteed medallions. Pork tenderloin is also often cut into medallions and then sauteed, which promotes considerable fond, allows a nice pan sauce, and makes for a nice presentation. Medallions are thin, and so more difficult to measure the temperature of directly with an instant read thermometer, but with experience (to avoid overcooking), this is another extremely effective technique.

With a pork tenderloin:

Season the meat, sear all sides in a very hot pan, and then finish in the oven at 350°F (175°C) degrees until the internal temp. hits 145°F (63°C). Then let it sit for 10 minutes, and cut 'er up.

If you need it done faster, a higher oven temp will accomplish this, but may compromise quality. But like I said, for a tenderloin, you don't want too low, or too high. Just watch the internal temperature, that is the key.

I agree, pork should never be overcooked or it will become nothing but a dry meat. I always season my pork tenderloins, then pan-sear for a crispy brown outer crust, then put into the oven at 350 degrees for about 45 minutes to one hour. At 45 minutes, I begin checking the internal temperature of the meat. When it reaches just under 150 degrees, I remove the roast from the oven and let sit uncoverd for 10 to 15 minutes. The roast will continue to cook internally while sitting and should rise approximately another 3 or 4 degrees. The meat should be a light pink color. If any more red, I suggest that you buy a new thermometer. Happy eating! :-)

Pan searing is a new delicious twist. But, I cook these all the time and don't need the extra dishes. I foil a pan, roll in olive oil in pan, nick and insert sliced fresh garlic cloves inbeded in roast, season with season and coarse ground black pepper, with oven sometimes pre-heated to 375, throw in for 25-30 minute, then check temperature looking for 150 degrees, flip over towards the end after the 25 min. mark, and... Shizam! Super delicious...

I cook mine in the smoker. Two hours at 225F take out at 145F/ nothing better.

Don't sear in advance.

Cook indirect heat (oven, back or side of BBQ w/burner turned off under the pork) until temps hit ~140.

Bring to high direct heat (high!) and develop level of sear/crust you prefer, let rest 10 minutes.

This will give you the best possible results. Searing in advance DOES NOT lock in the juices/result in moister meat, scientific testing in recent years in food kitchens has shown the exact opposite.

We were talking 145°F (63°C) not 165°F (74°C). I just tried it and the pork came out pink. Over here in the UK we like pink lamb and even steak tartare but pink pork will take another century or so despite what the US may tell us we are still advised to cook pork to 79°C (174°F).

I have fed my young children Pork Tenderloin for years without incident. With a convection oven set at 435 (actual temp 25 less = 410) I cook for 13 minutes @ actual 410 to kill bacteria, then set temp at 350 (actual will be 325) and cook @ 325 for 18-22 minutes depending on thickness of roast. I cut into to check color and never use an thermometer to check center. No incident here.

145 F may well break down collagen but does it kill the nasty little Trichinella spiralis that pigs can harbor. Thiat is why 205F for pork came into being because that ensured the little horrors were killed.